Inside

Finding the Cures

Elaine Tuomanen, MD
Study shows how pneumonia bacteria use stolen genetic material
In a new study, St. Jude researchers have gained insight into how pneumococcus, the primary cause of pneumonia, uses a particular piece of stolen genetic material to render it more virulent.
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Basic Science

The diverse research at St. Jude ranges from discovery-focused and hypothesis-testing laboratory studies to clinical trials of specific agents, regimens, or therapeutic interventions. We continually seek to translate knowledge acquired through basic research into novel approaches for clinical diagnosis and treatment. At the same time, our clinical and laboratory-based investigators use the challenges encountered in the clinic to focus the efforts of our research.

The Research Behind the Cures

Xin Geng, PhD and Guillermo Oliver, PhD

Researchers identify mechanism underlying genetic forebrain malformation

St. Jude scientists have identified one of the molecular mechanisms underlying the genetic brain malformation called holoprosencephaly (HPE). The findings not only yield insights into the most common developmental malformation of the anterior brain and face in newborns, but also help in understanding the intricate process by which the brain forms in the developing fetus.

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Scientific Report 2008

Scientific Report

Key research activities and publications by the investigators at St. Jude during 2007 are summarized in the Scientific Report 2008.

In the News

Terrence L. Geiger, MD, PhD
New clue to machinery of autoimmune disease
St. Jude researchers have discovered an intriguing insight into how T cells, the immune system’s master regulatory cells, wage war on the body’s own tissues in such autoimmune disorders as multiple sclerosis, type 1 diabetes and rheumatoid arthritis.
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Interactive / Multimedia