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St. Jude Children’s Research Hospital has been described as “a hospital without walls.” The St. Jude Domestic Affiliate Program’s mission is to extend care and benefits to more children; increase the number of children on St. Jude protocols; and to provide clinical, academic and financial support to our affiliates. The Domestic Affiliate Program is a network of pediatric hematology-oncology clinics, hospitals and universities united to extend the mission of St. Jude. The physicians and staff at these sites work in collaboration with the staff of St. Jude to deliver protocol-related care to pediatric hematology and oncology patients.